منابع مشابه
Protein secretion: Sorting sweet sorting
How are proteins sorted to different destinations in eukaryotic cells? Until recently, it was generally thought that the constitutive flow of proteins to the cell surface occurs by default, and that proteins simply accumulate carbohydrate modifications as they pass sequentially through each compartment along the secretory pathway [1]. This hypothesis was supported by studies showing that inhibi...
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The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.
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The organization of eukaryotic cells depends on correct targeting of proteins and lipids to the organelles at which they function, but how organelle identity is maintained in the face of a constant flux of material is a major problem for the cell. New mechanisms addressing this question were revealed at the Minisymposium on " Membrane Traffic: Dynamic and Regulation. " Starting with the endopla...
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Ubiquitin plays a fundamental role not only in proteasome-mediated protein degradation but also in the targeting of membrane proteins for degradation inside the lysosome. Ubiquitination provides a key signal for endosomal sorting of membrane proteins into the MVB (multi-vesicular body), which delivers its cargo to the proteolytic interior of the lysosome. Attachment of single ubiquitin molecule...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1996
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)70669-6